Need Help with screen face animations

SO i’m trying to get back into vr chat and blender, and one of the avatars im going to be working on has a screen for a face.
Is it possible to animate the face with 2D for a 3D model? If so how?? Any guides would be helpful, i havent been able to find anything about it
Would it technically be considered as shapekeys??

only way to do it would be shader or shape key.
and also depends on what kind of animating

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You can also animate material changes. So lets say you have material 1 as neutral, and material 2 is exactly the same but with a smile. You can animate in Unity the material swapping, and put that animation into the FX layer.

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